An accurate, simple, reproducible and sensitive method for the determination of paracetamol, cetirizine and pseudoephedrine was developed and validated. Paracetamol, cetirizine and pseudoephedrine were separated using a Hypersil C18 column by isocratic elution with a flow rate of 1.0 mL/min. The mobile phase composition was 25mM phosphate buffer (pH 5.0) – methanol – acetonitrile (30:60:10) (v/v/v) and 100 mg of heptane sulphonic acid was added for every 100 mL of mobile phase. Spectrophotometric detection was carried out at 240nm. The linear range of determination for paracetamol, cetirizine and pseudoephedrine were 100-600 μg/mL, 1-6 μg/mL and 12-72 μg/mL, respectively. The method was shown to be linear, reproducible, specific, sensitive and rugged.