Achillea millefolium L. commonly known as Yarrow is a perennial herb native to North America, Northern Asia, and Southern Europe. Plant belongs to family Asteraceae, which possess various medicinal healing properties for human life. Traditionally, its various parts like flowers, leaves and stems are being used as anti-inflammatory, antidysenteric, antiallergic, platelet aggregation, antipyretic, anti-bacterial, antispasmaodic, diuretic, urinary antiseptic, antimutagenic and in the treatment of hyperpigmentation of skin. A. millefolium contains active constituents like are luteolin, quercetin, apigenin, artemetin, betonicine, stachydrine, trigonelline, palmitic acid linoleic acid, aspartic acid, glutamic acid, camphor, linalool, azulene, chamazulene, sabinene, achillin, 1,8-cineole and many others. The present work highlighted the overall therapeutic potential of the yarrow (A. millefolium) and its preclinical reported activities in different disease.