Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

SbCl3-HAP catalyzed aza-Michael addition of aliphatic amines to α,β -unsaturated carbonyl compounds and nitriles

Author(s): Rajni Khajuria, Raj Kumar, Deepali Mahajan,* and Kamal K. Kapoor

An efficient aza-Michael addition of aliphatic amines (primary and secondary) to a series of α,β-unsaturated carbonyl compounds and nitriles has been carried out using antimony (III) chloride supported over hydroxyapetite (SbCl3-HAP) as an effective catalyst in acetonitrile to produce the corresponding β-amino derivatives in high yields. The method is simple, general and offers limited chemoselectivity, as aromatic amines were found to be unreactive.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?