Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Silica Perchloric acid catalysed synthesis of 2-Benzoyl-6-(3-arylsydnon-4-yl)- 4-aryl-2,3a,4,5-tetrahydro-3H-indazol-3-ones as antimicrobial agents

Author(s): Arunkumar Manohar Shirahatti, K. Maheshkumar, Sachin Prakash Ambekar, Oblennavar Kotresh

An efficient and practical procedure for the synthesis of 2-benzoyl-6-(3-arylsydnon-4-yl)-4-aryl-2,3a,4,5-tetrahydro- 3H-indazol-3-ones (4f-o) using inexpensive silica perchloric acid as heterogenous catalyst is described. The use of catalyst increased the yield of the product. The antimicrobial screening for the title compounds was carried out.


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