Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Simple spectrophotometric determination of rupatadine as rupatadine fumarate from pharmaceutical formulation

Author(s): Rajan V. Rele and Sachin S. Patil

Simple, sensitive and accurate extractive spectrophotometric methods have been developed for the estimation of rupatadine as rupatadine fumarate from pharmaceutical dosage form. The methods were based on the formation of coloured complexes by the drug with reagents like bromocresol green , eriochrome black-T and solochrome dark blue in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 416 nm, 511 nm and 527 nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1-12 μg/ml, 2.5 – 50 μg/ml and 100-600 μg/ml for methods I, II and III respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of rupatadine as rupatadine fumarate in tablets


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