A simple, rapid, precise and accurate isocratic reversed-phase HPLC method was developed and validated for the simultaneous determination of Dutasteride (DTA) and Tamsulosin (TMS) in commercial tablets. The method has shown adequate separation for DTA and TMS from their associated excipients of the tablets. Separation was achieved on a Waters C-18 Column with 250mm × 4.6 mm and 5 μm Particle size, using a mobile phase consisting of Acetonitrile (ACN): Water (90:10, v/v) at a flow rate of 1 ml/min and UV detection at 292 nm. The linearity of the proposed method was investigated in the range of 50-150 μg/ml (r = 0.9993) for DTA and 40-120 μg/ml (r = 0.9997) for TMS. The limits of detection were 0.17 ng/ml and 0.21 ng/ml for DTA and TMS, respectively. The limits of quantitation were 0.52 ng/ml and 0.65 ng/ml for DTA and TMS, respectively. This procedure was found to be convenient and reproducible for analysis of these drugs in tablet dosage forms.