Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Simultaneous estimation of amlodipine besylate and atenolol in combined dosage form by Vierodt’s method using U.V. spectroscopy

Author(s): P. Y. Pawar, B. Y. Mane, Sumit M. Auti and Vipul V. Trivedi

To develop the new method for simultaneous estimation of Atenolol and Amlodipine Besylate. Spectroscopic studies were carried out using double beam U.V.Spectrophotometer model JASCO.The marketed combination of Atenolol and Amlodipine Besylate that is Primol-AT 10 TAB Madley pharma and 0.1N HCL used as solvent. Then spectra of AML and ATN exhibit λmax of 239nm nand 228nm resepectively.Additionaly one isoisoprtive point was observed at 233nm this wavelength were selected for simultaneous estimation of AML and ATN and standard Calibration curves for AML and ATN were linear with correlation coefficient 0.996 and 0.993 at all selected wavelengths. This method was found to be applicable over a range of 4-24ug/ml for AMLand ATN.This method can be used as alternative for rapid and routine determination of bulk sample and tablets


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