Two simple, sensitive, rapid spectrophotometric methods have been developed for simultaneous estimation of Atazanavir Sulfate (ATV) and Ritonavir (RTV) in tablets. First method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 249.5 nm and 238.5 nm λ max of ATV and RTV, respectively. Second method is based on area under curve(AUC) and the wavelength ranges selected for analysis were 254.5-244.5 nm for Atazanavir Sulfate and 243.5-233.5 nm for Ritonavir. Beer’s law was obeyed in the concentration range of 10-50 μg/ml and 10-50 μg/ml for ATV and RTV, respectively. The methods were validated as per ICH guidelines. Statistical analysis proved that the methods were accurate, precise, and reproducible for analysis of ATV and RTV in tablets. The wide linearity range, sensitivity, accuracy and simple procedure imply that the proposed technique demonstrated to be appropriate for routine analysis and quality control assay of tablets.