Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Simultaneous spectrophotometric estimation of vildagliptin and metformin in bulk and tablet dosage form

Author(s): Baokar Shrikrishna, Mulgund S. V. and Ranpise N. S.

A simple, precise, accurate, cost effective and reproducible spectrophotometric method has been developed for simultaneous estimation of Vildagliptin (VIDA) and Metformin (MET) in combined tablet dosage form. The method employs measurement of absorbance at the wavelength of maximum absorptions of VIDA and MET using 0.1 N NaOH as a solvent. The calibration curve was linear in concentration range of 30-70 μg/ml for VIDA with correlation coefficient of 0.999 and 5-25 μg/ml for MET with correlation coefficient of 0.999. Accuracy of proposed method was confirmed by performing accuracy studies which showed the accepted results. Precision of proposed method was confirmed by performing intraday and inter day precision. All the results were well within acceptance criteria which indicates the method has excellent scope for simultaneous estimation of VIDA and MET in combined dosage form.


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