Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Spectrophotometric determination of some 1,4-dihydr opyridine drugs in their pharmaceutical preparations and spiked human plasma

Author(s): Mostafa A. Marzouq 1* , Mohamed A. El Hamd 1 , Sameh A, Ahmed 2 , Hassan F. Askal 3 and Gamal A. Saleh

A selective and validated spectrophotometric method was developed for the determination of some 1,4- dihydropyridines (1,4-DHPs) nifedipine, nicardipine , and nimodipine in pure form and pharmaceutical preparations. The proposed method is based on the c ondensation reaction of 1,4-DHP with p-anisaldehyde in acidic medium and measuring the absorbance at 460 nm. The absorbance- concentration plot was rectilinear over the concentration range of 5-60 μ g/mL with a minimum de tection limit of 0.72-2.08 μ g/mL. The factors affec ting the absorbance of the formed products were carefully st udied and optimized. The proposed method was applie d for the determination of these 1,4-DHPs in their pharmaceut ical preparations and spiked human plasma. The resu lts obtained were compared with those obtained using th e reported methods. Also proposal of the reaction p athway was postulated.


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