In view of the great biological, industrial and manifold applications of sulfamethoxazole and imidazole complexes, there is a need for an understanding of the coordination possibilities of sulfamethoxazole and imidazole. In this work, Cu(II), Co(II), Mn(II)and Zn(II) mixed-ligand complexes of sulpha drug (Sulfamethoxazole, L1) and imidazole (L2) in form of (L1: M: L2) (1:1:2), have been prepared and their infrared and UV-Vis spectra have been investigated. The infrared spectra of the samples were recorded in the range 4000-400 cm-1 and their fundamental vibrational wave numbers were obtained. The electronic spectra of all the synthesized complexes were recorded on Spectro-UV-Vis double beam PC scanning spectrophotometer UVD 2960. In all the complexes, SMX behaves as a Tridentate ligand binding through two Ar-N atoms and sulfonic oxygen while imidazole behaves as a monodentate with N donor atom. UV-Visible spectra suggest probable octahedral geometry for the complexes.