Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Stability indicating spectrophotometric assay of candesartan cilexetil and olmesartan medoxomil using discrete fourier transform convoluted curves

Author(s): Ekram M. Hassan*, Marwa K. El Jamal* and M. Abdelhady El Sayed

The manuscript describes the application of chemometry in proposing stability indicating assay for two hypotensive drugs as Candesartan Cilexetil (CAN) and Olmesartan Medoxomil (OLM).The use of Discrete Method of Fourier Transform Convoluted Spectra (FF method) and Derivative Ratio Method (D1R method) were found to be beneficial in eliminating the interference of the corresponding alkaline induced degradation and background noise.Hence, the methods can be used as stability indicating assay.The methods have been validated. The limit of detection (LOD) and limit of quantitation (LOQ), the linearity range, the regression coefficient and standard deviation of the slope gave satisfactory values. The methods gave comparable results through t- and F calculations during tablet assay.

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