Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Studies on synthesis of 2-(1-(1H-benzo(d)imidazol-2-yl)ethylthio)-6- methylpyrimidin-4-ol of potential pharmacological interest

Author(s): S. Kotaiah, B. Ramadevi, A. Naidu & P. K. Dubey

Ethyl acetoacetate (1) on condensation with thiourea (2) in methanolic KOH under reflux for 4-5 hrs, gave the earlier reported 2-mercapto-6-methylpyrimidin-4-ol (3). o-Phenylenediamine (4) on condensation with DL- lactic acid (5) under Phillip’s conditions gave 2-(α- hydroxyethyl)benzimidazole (6) which on treatment with SOCl2 gave the previously known 2-(α- chloroethyl)-1H-benzimidazole (7). Condensation of 3 with 7 in DMF containing K2CO3 as a base and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst gave 2-(1-(1Hbenzo( d)imidazol-2-yl)ethylthio)-6-methylpyrimidin-4-ol (8). Structure of 8 has been established on the basis of its spectral & analytical data.

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