Several of experimental studies and molecular investigations highlight the power of herbs to evidence-based medicine. In Algeria, a number of medicinal plants have been studied for the treatment of diabetes such as Haloxylon scoparium pomel and Atriplex halimus L., growing in arid and subarid areas, known for its hypoglycemic activity and widely used by the local population as remedy to treat diabetes mellitus. Reported to be used for anti-inflammatory. The objective of this review is assessing these plants extracts effect in vitro on the activity of α-amylase to give value to this important traditional medicinal plant as antidiabetic, and evaluate the anti-inflammatory potential. the inhibitory activity of the dichloromethane fraction A. halimus L. of α-amylase has a remarkable inhibition percentage, equal to 61.43% with an IC50 value equal to 0.5 mg/ml followed by the butanol fraction of rods haloxylon scoparium pomel 56.21% and the IC50 equal to 0.73 mg/ml. In fact, the dichoromethane extracts of the stems and flowers of the species Haloxylon scoparium pomel exhibit very high NO inhibition percentages at a concentration equal to 160 μg/ml The dichoromethane extract of the species Atriplex halimus L. demonstrates the With 97.6% inhibition of NO production at 160 μg/ml.