Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Study on the applications of some bis (hydroxyaryl) telluroxides as aldol catalyst

Author(s): Krishan K. Verma, Sapana Garg and Jitender K. Narwal

Bis (p-hydroxyphenyl) telluroxide and bis (3-methyl-4-hydroxyphenyl) telluroxide have been synthesized by alkaline hydrolysis of corresponding bis (hydroxyaryl) tellurium (IV) dichloride which in turn were obtained by reactions of TeCl4 with phenol and o-cresol respectively. These telluroxides have been investigated as aldol catalysts in the reactions of benzaldehyde / panisaldehyde with acetophenone, p-methyl-, p-chloro- and p-bromoacetophenones to yield the chalcones, which are known to be important class of medicinal compounds. It has been observed that the catalytic activity is more in case of bis (3-methyl-4-hydroxyphenyl) telluroxide as compared to bis (p-hydroxyphenyl) telluroxide, probably due to more basic nature of former.


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