Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Syntheses and characterisation of new diazaphospholes and phosphonic acids

Author(s): Chava V N Rao, Ch Rama Teerdha, Ashvin K Aggarwal, V Ram Manohar

Synthesis of diazaphospholes (1- 8) were accomplished by the condensation of 1, 2 -ethylene diamine with phosphorus oxychloride and the intermediate compound in situ treated with water or indole or 5-bromoindole. Synthesis of phosphonic acids and its derivatives (9-14) were obtained by reacting phosphorus oxychloride with indole or 5-bromoindole in presence of triethylamine. All these compounds were (1-14) colourless to brown coloured solids. These compounds structures were elucidated with the help of spectral data – IR, 1H NMR, 13C NMR and 31P NMR, MASS and Elemental analysis.


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