Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis , Biological Activity and Mass Spectra Investigation of 1,2,4- Triazino- [2,1-a]- 1,2,4- triazine Derivatives

Author(s): J.A. Hassanen , H .Kh Ashour and SH. A. Zkaria

2-(Aminothiocarbonyl)-3-phenyl-5-benzylidene-1,2,4-triazin-6-one (2) was prepared via the condensation of oxazolinon (1) with thiosemicarbazide under reflux. Treatment of compound 2 with bromoethyl aryl ketons and ethyl chloroacetate in presence of fused sodium cetate yield the corresponding 1,2,4 triazino-[2,1-a]-1,2,4-triazine derivatives (3and4) .Acylation of triazino-[2,1-a]-1,2,4-triazines (3 and4) with acetic anhydride afforded the corresponding N-acetyl derivatives (5and6).Condensation of compound 4 with aromatic aldehydes to give 2- arylidiene-4-thioxo-1,2,4-triazino-[2,1-a]-1,2,4-triazine-1,8-diones (7a,b).The electron impact mass spectra of both of the above series of fused 1,2,4-triazine derivatives have also been recorded and their fragmentation pattern is discussed. The prepared fused 1, 2, 4- triazino -[2,1-a]-1,2,4-triazine derivatives also exhibited antimicrobial activity and anti-cancer evaluation

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