Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis , reactions and antimicrobial activity on some novel phthalazinone derivatives

Author(s): Fatehia Korany Mohamed

A simple and efficient synthesis of [4-(3, 4-dimethylphenyl)-5, 6, 7, 8-tetrabromo-1-oxo-1Hphthalazin- 2-yl]-acetic acid hydrazide (IV) has been carried out. The obtained hydrazide (IV) has been used in synthesis of some interesting heterocycles such as pyrazolone, thiazolidinone,pyrimidine,benzoxazine lactam, rhodanine, quinazoline, benzoxazinone(VIII– XVII). Some of the prepared compounds tested for in vitro antibacterial activities. Among those tested, many compounds showed good antibacterial activities


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