Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and Antibacterial Activity of Novel Isoxazoline Derivatives

Author(s): Sailu B , Srinivas Mahanti , Satya Srinivas A, Balram B, Ram B, Taara B and Vasudha B

New isoxazoline derivatives (4a - 4l) were prepared from commercially available 2-Hydroxy-Aceto-Naphthanone and their antibacterial activity against four pathogenic bacteria, two Gram negative bacteria and two Gram positive bacteria. Majority of the isoxazoline analogues exhibited antibacterial activity comparable to ampicillin as reference drug.


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