Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and Antibacterial Evaluation of Some Novel Pyrazoline Derivatives

Author(s): Hareesh M, Srinivas Mahanti , Sailu B, Subramanyam D, Saidu Reddy Sakam, Tara B, Balram B, Vasudha B, Ram B.

New pyrazoline derivatives 4 (a -l) were prepared from commercially available 2-Hydroxy-Aceto-Napthanone and substituted vanillin derivative. These compounds were evaluated for their antibacterial activity against Escherichia coli (MTCC-443), Staphylococcus aureus (MTCC-96), Pseudomonas aeruginosa (MTCC-424) and Streptococcus pyogenes (MTCC-442) bacterial strains. Most of the compounds were found to be active compared to the standard drug ampicillin. In general it is observed that the compounds having amide functionality 4i-4l exhibited excellent antibacterial activity with zone of inhibiton 19-22 mm towards all the tested bacterial strains.


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