Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and anticancer evaluation of some fused pyrazolopyrimidines and their S-acyclic nucleosides

Author(s): Aymn E. Rashad, Ahmed H. Shamroukh, Dalia A. A. Osman,Samir T. Gaballah,Ahmed I. Hashem,Hatem S. ali, and Farouk M. E. Abdel-Megeid

6-Mercapto-1-(9-Methyl-5,6-dihydronaphtho[1',2':4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazolo[3,4-d]pyrimidin- 4-one (2) was prepared and used as a key compound for the preparation of some S-acyclic nucleosides of pyrazolo[3,4-d]pyrimidines 4-9. Also, the synthesis and structure characterization of pyrazolo[3,4- d][1,3]thiazolidino[3,2-a]pyrimidine 10 and pyrazolo[3,4-d][1,3]-thiazolo[3,2-a]pyrimidine 11 were described. Moreover, the cytotoxicity and in vitro anticancer evaluation of the prepared compounds have also been assessed against breast MCF-7 cancer and liver HepG2 cancer cell lines with investigation the effect of the synthesized compounds on the expression of urokinase plasminogen activator (uPA). The results revealed that, compounds 8 and 7 revealed promising anticancer activity compared to the activity of the commonly used anticancer drug, doxorubicin with inhibiting the expression of uPA.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?