Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and antimicrobial activity of 1-[(3,5-diphenyl substituted)-4,5- dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl) ethan-1-one derivatives

Author(s): Imaduddin Quazi, V. Girija Sastry, Javed Akhtar Ansari and S. H. Rizwan

Series of 1 of 1-[(3,5 diphenyl substituted ) -4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl) ethan-1-one (5a-5j) derivatives were synthesized by the reaction between indole 3 acetic acid hydrazide and various chalcones (3a-3j). The synthesized new compounds were identify by spectral studies and elemental analysis, and were evaluated in vitro for their antimicrobial activity.


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