Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and antimicrobial activity of 4-benzyloctahydropyrrolo- [3,4-b][1,4]oxazine derivatives

Author(s): Eswarappa Bheemappaa,Chandrashekar Aswathanarayanappab, Yadav D. Bodkeb, Peethamber S. K.

The novel bridged bicyclic morpholine derivatives, 4-benzyloctahydropyrrolo-[3,4-b][1,4]oxazine derivatives (6a-j) have been synthesized in six steps. The target compounds (6a-j) were obtained by reacting active intermediate 4- benzyloctahydropyrrolo-[3,4-b][1,4]oxazine (5) with various alkyl or aryl halide substituents in the presence of potassium carbonate. Thesebridged bicyclic morpholineswhich were fused to an additional hetero ring, pyrrolidinewere screened for their antibacterial and antifungal potency. These derivatives,N-substituted with cyclohexomethyl, isopropyl, p-methylbenzyl and phenylethylexhibited promising antimicrobial activity; compounds 6a-c were effective against the tested bacterial strains; compounds 6a, 6c, 6g were effective against antifungal strains; and compounds 6d and 6e were not active for these studies.

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