The new series of 2-mercaptobenzimodazole derivative were synthesized by using secondary amine i.e. diethyl amine and aromatic aldehyde. In Mannish reaction instead of formaldehyde other aromatic aldehyde was used. That was main aim of present study. The purity of synthesized compounds was checked by Melting point and TLC and their structure was established by various analytical techniques such as IR,1HNMR, Mass spectral studies.Thsese Compounds were screened for their Antimicrobial, Anticonvulsant activity. Antibacterial activity was screened by using Paper disc method. Anticonvulsant activity was evaluated by PTZ induced model.