Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and Antimicrobial Screening of Novel 5-(2-((1H-1,2,3-triazol-4-yl) methoxy)-2-phenylethyl)-3-methyl-4-nitroisoxazole Derivatives

Author(s): Budarapu Neelamma, Janapatla Uma Rani, Sunitha Vianala and Murali Krishna Thupurani

A library of novel bis-heterocycles encompassing isoxazole and 1,2,3-triazoles were synthesized by click chemistry approach and the structures of all newly synthesized compounds were confirmed by IR, NMR and MASS spectroscopic techniques. The synthesized final compounds (6a-m) have been tested for their antimicrobial activity. Results showed that compounds 6m, 6i, 6f and 6h posses significant antimicrobial activity.


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