Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and antimicrobial studies of some 4-Thiazolidinone containing Fluoroquinolones analogous

Author(s): Navin B. Patel and Sarvil D. Patel

A series of broad spectrum antibacterial fluoroquinolone attached to thiazolidinone 6a-j have been prepared and tested for their antibactial and antifungal in vitro activity against two Gram positive bacteria S. aureus, S. pyogenes and two Gram negative bacteria E. coli, P. aeruginosa and fungi C. albicans, A. niger and A. clavatus organisms by using Broth dilution method. Results indicated that the activity of fluroquinolones was not improved on incorporation of 4- thiazolidinone at C-3 and 4-methyl-2-phenylpiperazin-1-yl group at C-7.


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