Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and anti-mycobacterium study of some fluorine containing schiff bases of quinoline and their metal complexes

Author(s): Mustapha C. Mandewale, Bapu R. Thorat and Ramesh S. Yamgar

Five new quinoline Schiff bases were synthesized starting from 6-fluoro-2-hydroxyquinoline-3-carbaldehyde. In the reaction sequence, Fluorine substituted anilines were condensed to 6-fluoro-2-hydroxyquinoline-3-carbaldehyde. Further Zn (II) and Cu (II) complexes of Schiff bases were synthesized. Structure of synthesized compounds has been confirmed by employing various spectroscopic techniques like H1NMR, FTIR and Mass Spectroscopy. The newly synthesized Schiff bases and their Zn (II) and Cu (II) complexes were evaluated for their anti tuberculosis activity against Mycobacterium tuberculosis. Initial results indicated that most of the Schiff base derivatives and their metal complexes demonstrated very good anti tuberculosis activities. The most effective compounds SB01 to SB05 series and C01-C05 series have exhibited an MIC value in the range of 1.6 to 3.2 μg/ml against M. tuberculosis H37Rv strain that is comparable to first line anti-tuberculosis drug. Fluorescent properties of synthesized Schiff bases as well as metal complexes were studied.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş