Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and antitumor activity of some new 1,3,4-oxadiazole, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives attached to 4-benzothiazol-2-yl phenyl moiety

Author(s): Wageeh S. El-Hamouly, Kamelia M. Amin, Samy A. El-Assaly and Eman A. Abd El-Meguid

Some 1,3,4-oxadiazole, pyrazole and pyrazolo[3,4-d]pyrimidine derivatives were synthesized starting from o-aminothiophenol 1 by reacting with different electrophilic and nucleophilic reagents. Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF7), compound 6c exhibited the highest activity.


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