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Synthesis and antitumor activity of some new N-substituted-sulfonyl, 1,2,4-triazole, N-substituted-benzylidene and pyrrole derivatives attached to 4-(benzo[d]thiazol-2-yl)benzohydrazide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis and antitumor activity of some new N-substituted-sulfonyl, 1,2,4-triazole, N-substituted-benzylidene and pyrrole derivatives attached to 4-(benzo[d]thiazol-2-yl)benzohydrazide

Author(s): Wageeh S. El-Hamouly, Kamelia M. Amin, Samy A. El-Assaly and Eman A. Abd El-Meguid

Some N-substituted-sulfonyl, 1,2,4-triazole, N-substituted-benzylidene and pyrrole derivatives attached to 4-(benzo[d]thiazol-2-yl)benzohydrazide were prepared starting from oaminothiophenol 1 by reacting with different electrophilic and nucleophilic reagents. Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF7), compound 12a exhibited the highest activity.


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