Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and biological activities of novel 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles
Author(s): K. Ilango and P. ValentinaNew series of 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1,3,4-thiadiazoles (5a-j) have been synthesized by condensation of 3-aryl substituted-4-amino-5-mercapt-(4H) - 1, 2, 4-triazole (4a) with various aromatic acids in the presence of phophorus oxychloride. The structure of synthesized compound was supported by elemental analysis, IR, 1HNMR and mass spectral data. The compounds 5a-j was screened for antifungal activity against Candida albicans and Aspergillus niger and antioxidant activity by DPPH and Nitric oxide methods. Among all the synthsised products, the compounds 5d, 5f and 5h bearing hydroxy phenyl ring in 6th position of triazolo-thiadiazole exhibited significant antifungal activity with MIC value at 6.25 μg/ml. All the compounds showed moderate to good antioxidant activity by both the methods.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
