Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and biological activities of novel heterocyclic chalcone derivatives by two different methods using anhydrous potassium carbonate as an efficient catalyst

Author(s): Kulathooran S, Selvakumar B, Dhamodaran M

A series of twenty heterocyclic chalcones 3(a-t) were synthesized by using conventional and microwave irradiation methods in the presence of anhydrous potassium carbonate as an safe, inexpensive and efficient basic catalyst. Synthesized compounds were evaluated for their in vitro antimicrobial activity against variety of microbial strains and it was characterized by IR, NMR (1H & 13C) and mass spectral analysis. The biological screening results indicated that some of the compounds showed significant antibacterial and antifungal activities. Compound 3s was displayed excellent antimicrobial activity against various microbial strains. The newly synthesized high potent compound 3s was subjected to Thermogravimetric analysis (TGA), Differential scanning calorimetric (DSC) and single crystal XRD


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