Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and biological activity of novel phthalamide containing azitidinone

Author(s): Gunvantsinh T. Desai, F. B. Bux and Arun Singh

4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylidene-4-(1,3-dioxoisoindolin-2-yl)benzohydrazide (2a-e) in good yields. Cyclocondensation of compounds (2a-e) with chloro acetyl chloride yields N-(3-chloro-2-oxo-4- arylazetidin-1-yl)-4-(1,3-dioxoisoindolin-2-yl)benzamide (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?