Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis and biological evaluation of 3-(4-chloro-1-hydroxynaphthalen-2-yl)- 5-aryl-1-substituted-pyrazoles

Author(s): V. M. Sherkar and S. E. Bhandarkar

Pyrazoles are heterocyclic compounds with five member ring, with two nitrogen atoms in adjacent position. They shows excellent biological activities such as antimicrobial, anti-inflammatory, anticancer, analgesic, anticonvulsant, anthelmintic, antioxidant and herbicidal. So it was thought to synthesized these compounds and study their antimicrobial and antifungal activities. 4-Chloro-2-(1-substituted-5-aryl-pyrazolin-3-yl)-naphthalen-1- ols were suspended in DMSO in 250 ml R.B.flask fitted with condenser and then crystal of Iodine was added to it. The reaction mixture was stirred and refluxed for 1 hour 30 Min. The contents were cooled and diluted with water . The product obtained was filtered and washed with 10% aqueous sodium thiosulphate and crystallized from ethanol acetic acid mixture to obtained 3-(4-chloro-1-hydroxynaphthalen-2-yl)-5-aryl-1-substituted-pyrazoles. The synthesized compounds were characterized by elemental analysis, 1H NMR, IR Spectroscopy. All Newly synthesized compound were scanned for their biological activities specially antimicrobial and antifungal activities and all newly synthesized compounds shows an excellent antimicrobial and antifungal activities.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
 
Erkek öyle sert ve acımaz sikiyor ki bayan çaresiz bir şekilde tırtıl misali sikiş yataktan aşağı doğru kayıyor fakat hem adam hemde kadın aşırı mobil porno derecede zevk alıyorlar Uzun zamandır karısı ile ilgili planları olan türk porno adam onu başkaları sikerken hayal ediyor bu durumu karısından sikiş izle gizliyordu fakat bir gün adamın moralinin bozuk olduğunu anlayan karısı sikiş ona ne olduğunu sordu ve adamda ona her şeyi anlatmıştı karısı bu porno resim durumdan Büyük zenci yarağı sevenler için özel olarak eklenmiş videomuz türk porno kalın ve damarlı zenci siki arayıp bulamayanlar için özel olarak sikiş izle yayınlanmıştır filmde ise sarışın zengin sürtük büyük mobil sikiş kalın damarlı alet sevdiğini bir çok kez dile getirmiş