In our ongoing research efforts to improve and develop new treatment strategies against oxidative stress, we develop simple and efficient methods to synthesis a new derivatives as stable free radical scavenger through conjugation of the different moieties to enone 8a-c & 16 as starting compounds and containing different active parts as indoline (9a-c,11a-c, 12a-c &13a-c), quinoline 10a-f, pyrimidine 15a,b and pyridine 17. In addition, the UV absorption by some representative members indicated lmax in the range of 400-320nm (UVA) as in compound 17 and lmax in the range of 320-290nm (UVB) as in 9b. This finding represents an indication that these compounds might proof themselves as photoprotectors. This might be due to their characteristic structure that can scavenge free radicals and protect the skin against their harmful effects and they can be applied topically. Moreover, they were evaluated pharmacologically for their in vitro antioxidant activity using L-ascorbic acid as positive control according to ABTS antioxidant assay, Erythrocyte hemolysis and Bleomycin depended DNA damage methods and the structures were confirmed by elemental analysis as well as 1H NMR, IR and mass spectral data.