Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and biological evaluation of some novel isatin derivatives as antimicrobial agents

Author(s): H. Ramadoss, D. Saravanan, S. P. N. Sudhan and S. Sheik Mansoor

A new and convenient procedure has been developed for the one-pot synthesis of different types of isatin derivatives from isatin, malononitrile, and cyclic 1,3-dicarbonyl compounds using tetrabutylammonium bromide (TBAB) as an inexpensive, non-toxic, non-metallic and readily available catalyst in ethanol under reflux condition. The compounds were screened for their antimicrobial activity. Antimicrobial studies showed that all the target compounds processing good antibacterial and antifungal activities.

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