Abstract

Synthesis and biological evaluation of some novel quinoxalinyl triazole derivatives

Author(s): Joydeep Mazumder, Raja Chakraborty, Saikat Sen, Sanjay Vadra, Biplab De, T. K. Ravi

The druglikeness score and bioactivity of the assumed triazole derivatives of the quinaxoline was calculated by determining various parameters as defines by Lipinski's rule. All the derivatives are also screened for bioactivity by calculating the score for GPCR ligand, ion channel modulator, kinase inhibitor, nuclear receptor ligand. The sufficient modification in the structure was done to achieve ideal scores for showing biological activity, which was compared with standard drug. In the present study, 2,3-diphenylquinoxaline-6-carboxilic acid has been prepared from benzyl. Triazole derivatives were prepared by reacting with different aldehyde in presence of ammonium acetate and ammonium hydroxide. The synthesized compounds was characterised by 1H NMR and mass spectral data. All the compounds have been screened for their antibacterial and antifungal activity. Compounds have shown good antifungal activity. Among them fluoro derivative have shown highest activity as it has almost close druglikeness score in compare to the standard fluconazole. No compound has shown antibacterial activity.

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