Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and characterization of multifunctional polymers bearingactive ingredients

Author(s): F. Z. Kermezli, F. Z. Sebba and S. Ould Kada

The synthesis of poly(epichlorohyrin) was investigated using ring opening polymerization of epichlorohydrin amorced with perchloric acid in dichloromethane in the presence of methanol at 35 °C. The chemical modification of the obtained polymer was performed using the phase transfer method, by reacting poly (epichlorohydrin) with acetylsalicylic acid (ASA) then with menthol in an aqueous sodium hydroxide solution in the presence of tetrabutylammonium hydrogenosulfate (TBAH). The obtained polymers were characterized by FT-IR spectroscopy and 1H NMR.

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