Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and Characterization of Novel Amide Derivatives of Nitro-Imidazole

Author(s): K. T. Raut and P. J. Shirote

Synthesis of Amide derivatives of Nito-imidazole were investigated. various amide derivatives of 1-(2-chloroethyl)- 5-nitro-1H-imidazole-2-carboxylic acid (III) (derived From Metronidazole) have been synthesized by condensing them with sulfanilamide, sulfamethoxazole, sulfadiazine, Sulfanilic acid, sulfacetamide and isoniazid. Phosphorus Oxychloride is used as condensing agent. Structures of all derivatives were established on the basis of elemental analysis IR, and 1H NMR spectral data.

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