Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and characterization of Tenofovir disoproxil fumarate impurities, anti HIV drug substance

Author(s): Dipak Varal, Mandar Joshi, Deepak Panmand and Vidyadhar Jadhav

In the process development of Tenofovir disoproxil fumarate specified known, specified unknown and unidentified impurities found. The present work describes synthesis and characterizations of USP related known and unknown impurities; mono-POC Tenofovir (5), mono-POC methyl Tenofovir (6a), mono-POC ethyl Tenofovir, (6b), mono- POC isopropyl Tenofovir (6c), Tenofovir isopropyl isoproxil (7) and Tenofovir disoproxil carbamate (9). Identification of these impurities can be useful for quality control purpose in the manufacture of Tenofovir disoproxil fumarate.

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