Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and characterization of thiadiazole containing Schiff base: Antimicrobial activity.

Author(s): Naveen Kumar RM, Shiva Prasad K, Chandan S, Prasad N

A reaction of primary amine, 5-ethyl-1,3,4-thiadiazol-2-amine (1) with substituted aldehydes afforded a new class of imine group containing compounds (3, 5 and 7). The synthesized compounds were characterized by using spectroscopic techniques viz., 1H-NMR, 13C-NMR and mass spectral studies. Antimicrobial activity was done using disc diffusion technique using Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Ralsotonia solanacearum and antifungal activity against Aspergillus niger, Aspergillus flavus and Alternaria solani. All the synthesized compounds exhibited potent antimicrobial activities.


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