Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and evaluation of new 2,3- and 2,4-disubstituted quinazoline derivatives as potential antibacterial and antifungal agents

Author(s): Mahr A. El-Hashash, Dalal B. Guirguis and Yaser A. El-Badry

We report here the sythesis of 2,3-disubstituted quinazolinone derivatives via interaction of 2- methyl-6,8-dibromo-(4H)-3,1-benzoxazinone with nitrogen nucleophiles namely, hydrazine hydrate, sulpha drugs, and 4-aminoacetophenone. Also Synthesis of 4-chloroquinazoline (11) has been achieved via chlorination of the corresponding 6,8-dibromoquinazoline analog. The simple replacement of the chlorine atom at the 4-position of quinazoline nucleus with different nitrogen and carbon nucleophiles has produced derivatives of the 4-heteroaryl-quinazoline derivatives and fused quinazolines.Some of the synthesized compounds are tested for its antimicrobial activity.


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