Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis and evaluation of new phenylamino-thiadiazolo-oxadiazolo-1, 3-benzoxazoles for their antifungal and anti-inflammatory activity
Author(s): L. Srikanth, Usha Naik, Ramesh Jadhav, N.Raghunandan, J. Venkateshwar Rao and K. Raj manoharIn view of various biological activities of benzoxazoles, thiadiazoles and oxadiazole derivatives, it was our interest to prepare benzoxazole derivatives involving 1,3,4-thiadiazole and 1,3,4- oxadiazole nucleus and evaluate them for antifungal and anti-inflammatory activity using carrageenan induced rat paw edema model. The structures of all the synthesized compounds were characterized by IR, 1H-NMR and MASS spectral data. All the synthesized compounds were screened for antifungal and anti-inflammatory activity. Among all the active compounds thiadiazole and oxadiazole derivatives showed good activity.
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Citations : 25868
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