GET THE APP

Synthesis and evaluation of some novel thiophenes as potential antibacterial and mycolytic Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and evaluation of some novel thiophenes as potential antibacterial and mycolytic Agents

Author(s): Sajal Srivastava and Barnali Das

A series of tetrahydrobenzothiophene was synthesized with an objective to develop novel and potent amtimicrobial agent of synthetic origin. First, N- propylamine and Ethyl cyanoacetate were reacted to yield Propyl cyanoacetamide I. Then, compound (I) was reacted with cyclohexanone to obtain an intermediate, which was processed to 2-amino-3-N- (propylcarboxamido)- 4, 5, 6,7-tetra hydrobenzo (b) thiophene (II) by well known and versatile Gewald reaction. Reaction of compound II with different aromatic aldehyde yielded the title compound IIa-k. The synthesized compound were purified, characterized and evaluated for antimicrobial activity. Most of the compound exhibited moderate to significant activities.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry