Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and In vitro Antimicrobial Evaluation of 6-Aryl-4-(1,1'-biphenyl-4-yl)-Nmethyl-6H-1,3-thiazin-2-amines

Author(s): Ingarsal N, Sivagami S

Spectral characterization and antimicrobial screening of new 6-aryl-4-(1,1'-biphenyl-4-yl)-N-Methyl-6H-1,3-thiazin-2-amines synthesized from 1-(1,1'-biphenyl-4-yl)-3-arylprop-2-en-1-ones using N-methyl thiourea have been described. The isolated crude products were subjected to column chromatography and used for further analysis. The in vitro antimicrobial study of all synthesized compounds exhibited bacterial activity equal or moderate to the commercial antibiotic moxifloxacin but they were moderate to less active against standard fungi amphotericin B.


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