GET THE APP

Synthesis and pharmacological screening of some novel chloro chalconesemicarbazone derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis and pharmacological screening of some novel chloro chalconesemicarbazone derivatives

Author(s): Hemendra Pratap Singh, C S Chauhan, S N Pandeya, C S Sharma, B Srivastava, Manmohan Singhal

A series of chalconyl derivatives of chloro phenyl semicarbazide (CA1-CA5) was synthesized. All the synthesized compounds were screened for their pharmacological action in protection of seizures, behavioral study, anti-inflammatory and analgesic activity. After intraperitoneal injection to mice or rats, the synthesized compounds were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (scPTZ), and neurotoxicity test models. Compound CA6 emerged as the most active molecule for anticonvulsant and anti-inflammatory activity. Some of the title compounds exhibited lesser CNS depression compared to phenytoin as was evident from the CNS studies


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry