Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis and spectroscopic study of new substitute d phosphoramidates and 1,3,2-diazaphospholidine-2,5-diones

Author(s): Fouzia Bouchareb*, Malika Berredjem and Nour-Eddine Aouf

A new series of substituted 1, 3, 2-diazaphospholid ine-2,5-diones was synthesized by an efficient meth od, starting from a primary amines and amino esters. We have est ablished that phenyl phosphonic dichloride is a sui table reagent allowing the introduction a phosphoryl grou p. We have prepared the phosphoramidates in two ste ps. These compounds provide access to 1, 3, 2- diazaphospholi dine-2,5-diones by intramolecular cyclization using potassium carbonate.


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