Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and study of 3-(chloroaryl)-5-aryl-1-substituted pyrazolines with various percentage of 1,4-dioxane at different temperature and their effect on vegetable crop plant growth

Author(s): A. O. Deshmukh* and P. B. Raghuwanshi

The 2-Hydroxy-5-chloroacetophenone (IIIa) was prepared by Fries migration of p-chlorophenol acetate (IIa) in presence of AlCl3, The 2-hydroxy-3-bromo-5-chloroacetophenone (IIIb) was prepared by the bromination of acetophenone (IIIa) with bromine in acetic acid, and 2-hydroxy-3-nitro-5-chloroacetophenone was prepared by the nitration of acetophenone (IIIa) with nitrating mixture, then Acetophenone (IIIa-b) on condensation with aldehydes (benzaldehyde and chlorobenzaldehyde) gave corresponding chalcones. and finally,The pyrazolines (Va-Vf) were synthesized by reacting chalcones with thiosemicarbazide in ethanol.The ligand structure were elucidated on the basis of molecular weight,elemental analysis and their spectral data.

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