Thiazolidinone was synthesized by using Thiourea and chloroethylacetate. Chromene derivative were synthesized by Vilsmeier-Hack reaction using substituted Hydroxy Benzoic Acid. Initially synthesized Thiazolidinone and Chromene derivative were condensed using alcohol as a solvent. Further synthesized compounds were characterized by elemental & spectroscopic analysis. Compounds were further evaluated for in-vitro Anti- Inflammatory activity.