Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Synthesis and study of chlorosubstituted 4-aroyl/alkoyl pyrazoles and isoxazoles and their impact on phytotic growth of some vegetable crop plants

Author(s): C. L. Deotalu and P. R. Rajput

Aroyl/alkoylacetophenones (2a-b) undergoes intramolecular claisen condensation to form 1-(2’- hydroxy-3’,5’-dichlorophenyl)-3-aryl/alkyl-1,3-propanediones (4a-b) which on treatment with aromatic and aliphatic aldehydes in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones (5ab) subsequently 3-aroyl/ alkoylchromones (6a-b). 3-Aroyl/alkoylchromones (6a-b) on treatment with Ph.NH.NH2.HCl in DMSO containing small amount of piperidine gave 4-aroyl/alkoylpyrazoles (7a-b).So also 3-aroyl/alkoylchromones (6a-b) on treatment with NH2OH.HCl in DMSO containing a small amount of piperidine gave 4-aroyl/ alkoylisoxazoles (8a-b). The structures of newly synthesized chlorosubstituted 4-aroyl/alkoyl- pyrazoles (7a-b) and 4- aroyl/alkoylisoxazoles (8a-b) were elucidated on the basis of molecular weight, elemental analysis and their spectral data.

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