Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Synthesis, antihelmintic and insilico evaluation of 5-(substituted styryl)-5- (benzylideneamino)-1, 2, 4-triazolidine-3-ones

Author(s): K. Sudha Rani, D. Rajesh, Kandula Priyanka and K. N. V. Chenchu Lakshmi

A series of 5-(substitutedstyryl)-5-(benzylideneamino) - 1, 2, 4-triazolidine-3-one derivatives were synthesized by condensation of oxazol-5-ones by reaction of hippuric acid and different aldehydes with semicarbazide. Structures of the compounds were characterized on the basis of IR, 13CNMR and 1H NMR. Compounds 1b-12b were screened for antihelmintic activity .Test results revealed that compound 7b and 11b showed paralysis time of 3.3 and 3.1 min and death time of 4.1 and 4.5 min while the standard drug albendazole showed paralysis time of 11 min and death time of 21min, respectively, at the same concentration of 50mg/ml. All compounds were found to posses both vermifuge and vermicide properties.


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